Ongoing coronavirus (COVID-19) updates and resources for integrative healthcare professionals
Vaccination and Treatment Tracking
Scientist around the world are racing to produce a safe an effective COVID-19 vaccine. There are currently over 100 vaccine programs underway, with 54 vaccines in clinical trials on humans and 87 preclinical vaccines being tested in animals.
Vaccines typically require years of research and testing, including preclinical testing and multiple safety and efficacy trials before approval. The preclinical phase includes testing a new vaccine on cells and animals such as mice to see if it produces an immune response. Phase 1 assesses its safety in healthy people, phase 2 observes its effect on different cohorts of healthy people, and phase 3 monitors safety and efficacy on a larger scale. The final stage is approval, in which federal regulatory agencies review trial results and determine it is approved or not.
Some of the latest vaccine-related updates include:
- FDA authorizes Moderna vaccine for emergency use
- Cuba’s Soberana 2 vaccine moves to Phase 2.
- Japan’s Shionogi launches a Phase 1/2 trial.
- South Korea’s GeneOne enters Phase 1/2.
- Clover Biopharmaceuticals moves to Phase 2/3.
- BioNTech, Pfizer, and Fosun Pharma mRNA vaccine (combined phase 2 and 3): emergency use authorization
- Moderna and National Institutes of Health messenger RNA (mRNA) vaccine (phase 3): emergency use authorization
- CanSino Biologics and Academy of Military Medical Sciences adenovirus (Ad5) vaccine (phase 3): approved for limited use in China
- Gamaleya Research Institute Gam-Covid-Vac vaccine (phase 3): approved for limited use in Russia
- Beth Israel Deaconess Medical Center and Johnson & Johnson Adenovirus 26 vaccine (phase 3)
- AstraZeneca and the University of Oxford (combined phases 2 and 3)
- Vector Institute vaccine (combined phases 1 and 2): approved for limited use in Russia
- Novavax protein-based vaccine (phase 3)
- Wuhan Institute of Biological Products and Sinopharm inactivated virus vaccine (phase 3): approved for limited use in China, UAE, Bahrain
- Sinopharm and Beijing Institute of Biological Products inactivated virus vaccine (phase 3): approved for limited use in China, UAE
- Sinovac Biotech inactivated vaccine (phase 3): approved for limited use in China
Click here to track COVID-19 vaccine development in real time.
There is no known cure yet for COVID-19. The FDA has approved remdesivir for treatment of COVID-19 in certain situations. Additionally, the FDA has granted emergency use authorization for some treatments. However, further trials are needed to demonstrate widespread safety and effectiveness.
The following is a list of treatments and interventions currently under clinical investigation in order from most promising to least promising:
- Dexamethasone and corticosteroids
- Recombinant ACE-2
- Convalescent plasma
- Monoclonal antibodies
- Cytokine inhibitors
- Blood filtration systems
- Stem cells
- Vitamin and mineral supplements, including vitamin C, vitamin D, and zinc
Other supportive treatments to help patients with COVID-19 include prone positioning and ventilators and other respiratory support devices.