- Digital Summit
When thinking about risk factors for heart disease, many don’t fully appreciate the role mitochondria. Research has shown that the lower the mitochondrial DNA copy number, an increased risk for cardiovascular disease. Mitochondria dysfunction is involved in the development of many cardiovascular diseases. Researchers have shown that mitochondria dysfunction in hypertension and heart failure.
Mitochondrial dysfunction may be to blame for—or at least play a role in—the development of other cardiovascular diseases like atherosclerosis and cardiac hypertrophy. Mitochondrial dysfunction harms the heart with insufficient energy production and excessive amounts of ROS—leading to free radical damage further compromising performance and cellular health.
Clustering the risk factors for heart disease, then you have what’s called metabolic syndrome. These risk factors include high blood pressure, high blood sugar, excess belly fat, high cholesterol, and high triglyceride levels. Mitochondrial dysfunction occurs either before or during the development of these risk factors.