New study sheds light on diet quality and microbiome composition
A high-quality diet is linked to more potentially beneficial bacteria, while a low-quality diet is associated with an increase in potentially harmful bacteria, according to a new study by researchers at the Baylor College of Medicine in Houston, Texas.
It is well-established that diet influences health and disease, but the mechanisms underlying this effect are not fully understood. The researchers propose that modifying the microbiome through diet may be a part of a strategy to reduce the risk of chronic diseases.
In this study, rather than looking at individual diets, researchers led by Li Jiao, MD, MS, PhD, focused on dietary patterns as defined by the Healthy Eating Index (HEI)-2005 and how they relate to the microbiome.
The team used next-generation sequencing techniques to analyze the type and abundance of bacteria present in colonic mucosal biopsies. The samples were obtained endoscopically from enrolled consenting 50- to 75-year-old participants who had a colonoscopy at the Michael E. DeBakey Veterans Affairs Medical Center in Houston between 2013 and 2017. The participants were polyp-free and seemingly healthy. They reported their dietary consumption using a food frequency questionnaire before the colonoscopy.
Diet is considered a principal factor influencing the structure of the microbial community in the gut, which in turn significantly affects the ability of beneficial or harmful microbes to colonize it. The human gut microbiome also influences nutrient uptake, synthesis of vitamins, energy harvest, chronic inflammation, carcinogen metabolism, and the body's immune and metabolic response, factors that can affect disease risk, Jiao said.
"One new contribution to this work is that we looked at the microbiome associated with colonic mucosa," Jiao said in a statement released by the university. "Most other studies of the human gut microbiome have used fecal samples. We looked at colon mucosal-associated microbiome because we know that this microbiome is different from that in the fecal samples, and it is said to be more related to human immunity and the host-microbiome interaction than the microbiome in fecal samples."
Jiao and her colleagues found that a good-quality diet as the one recommended by the Dietary Guidelines for Americans to be high in fruits, vegetables and whole grains, and low in added sugar, alcoholic beverages and solid fats is associated with higher abundance of beneficial bacteria such as those with anti-inflammatory properties. A poor-quality diet, on the other hand, is associated with more potentially pathogenic bacteria, such as Fusobacteria, which has been linked to colorectal cancer.
The researchers propose that the effect diet has on the structure of bacterial communities in human colonic mucosa can lead to modifications of innate immunity, inflammation and the risk of chronic diseases.
Their next step is to confirm the study findings in a larger study population. In addition, they want to investigate how bacterial products, or metabolites, such as short-chain fatty acids or secondary bile acids, can modify tissue microenvironment into one that either inhibits or promotes tumor growth or development of other diseases. In addition, Jiao and her colleagues are interested in investigating how the unfavorable gut microbiome in individuals consuming a poor diet would respond to tailored dietary intervention using diet, pre- or probiotics, as previous studies have produced mixed results.
"Other factors, such as aging, genetics or certain medications, also influence the risk of disease but we cannot modify them," Jiao said. "Diet, on the other hand, can be modified and thus provides a strategy to develop a microbiome that promotes healthy living. We suggest that modifying the microbiome through diet may be a part of a plan to reduce the risk of chronic diseases."