Clinical Application of Synbiotics

The complex ecosystem of the gut microbiome supports numerous and important metabolic functions in human physiology, from modulating normal immune function and supporting healthy digestive function to producing vital nutrients and bioactive compounds. Because of the expansive metabolic impacts associated with the gut microbiome, utilizing opportunities to influence and manipulate its composition offers a profound strategy in addressing systems medicine and chronic disease.

For example, it’s well accepted that probiotic supplementation can improve health across various biological systems by promoting favorable microbiome balance, and that the complementary actions of prebiotics support metabolic functions by inducing the growth and activity of beneficial microorganisms.  However, it has increasingly been shown that synbiotics, as strategic combinations of probiotics and prebiotics, modify GI microbiota so profoundly as to exert an even greater impact on GI ecology than probiotics or prebiotics alone.

Emerging research surrounding synbiotics—the next generation of microbiome-supporting supplements—and their role in enhancing human health has accelerated in the past 10 years. But, when addressing patient health needs associated with microbiome ecology, how does this collective research concerning synbiotics translate to practical clinical applications?

In this whitepaper, we will:

1. Review current understandings concerning the effects of probiotics, prebiotics, and synbiotics on human health.
2. Discuss the mechanisms associated with the beneficial actions of synbiotics.
3. Explore the clinical application of synbiotics to support gut microbiome balance and enhanced human health.

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