- Digital Summit
Presented by: Donald Abrams, MD
Delta-9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis, was licensed and approved for the treatment of chemotherapy-induced nausea and vomiting in 1985. Due to the significant barriers to studying the potential therapeutic effects of the parent botanical, the medical literature does not support the strong anecdotal impression that cannabis itself is effective for this indication. Cannabis is also the only antiemetic agent that is also purported to be an appetite stimulant that is also a useful attribute in patients with malignant diagnoses.
There is an increasing body of evidence that cannabis is analgesic by itself and perhaps interacts synergistically with opiates. Animal models suggest that cannabinoids might be effective in treating as well as preventing chemotherapy-induced peripheral neuropathy although no clinical trials in humans have been conducted to date. The fact that we have a system of cannabinoid receptors and endogenous cannabinoids and the postulated function of this network supports the notion that cannabis would be a useful analgesic agent.
Cannabis may also be beneficial in the management of anxiety, depression