Luteolin May Prevent Hair from Graying, Study Finds

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Graying hair is widely recognized as a hallmark of aging, often accepted as an inevitable process. However, recent research from Nagoya University in Japan suggests that an antioxidant may suppress this process. The study, published in Antioxidants, identified luteolin, an antioxidant found in vegetables such as celery, broccoli, carrots, onions, and peppers, as a potential anti-graying agent. Researchers say the findings open the door for potential applications in human hair care.

The study, led by Masashi Kato, PhD, and Takumi Kagawa, PhD of  Nagoya University examined the effects of three antioxidants—luteolin, hesperetin, and diosmetin—on mice bred to experience graying similar to humans. The results showed that mice that received luteolin retained their black fur, while their untreated counterparts turned gray. This effect was observed regardless of whether luteolin was administered externally or internally.

“This result was surprising,” said Dr. Kato. “While we expected that antioxidants may also have anti-graying effects, only luteolin, not hesperetin or diosmetin, demonstrated significant effects. This finding suggests that luteolin may have a unique medicinal effect that prevents graying.”

According to the authors, luteolin’s effectiveness appears to be closely linked to its influence on endothelins—proteins that play a crucial role in cellular communication. The study found that luteolin treatments preserved the expression of endothelins and their receptor. This preservation supports healthy signaling pathways, preventing the decline in melanocyte activity that typically leads to graying.

“Interestingly, luteolin had limited effects on hair cycles, indicating that its primary impact is on pigmentation rather than hair growth or shedding,” Dr. Kato explained. “This targeted action makes luteolin a particularly intriguing candidate for addressing age-related hair graying.”

The similarities between the graying processes in the model mice and humans provide promising prospects for translating these findings into human applications. According to the study, luteolin is already available as a supplement for both topical and oral use, making it a strong candidate for development as an anti-graying treatment.

Building on these promising results, Dr. Kagawa envisions broader applications for luteolin in age-related research. “It would be interesting to investigate whether luteolin’s anti-aging effects could also be applicable to other age-related changes, including balding.”

As research progresses, luteolin could become a key ingredient in hair care regimens, helping individuals preserve their natural hair color as they age.