How Much Do You Know About Kaempferol?
Flavonoids are a group of compounds found in a variety of natural sources from fruits, vegetables, and tea to bark, roots, and stems that have been widely studied over the past few decades. Kaempferol is one of those flavonoid compounds found in fruits and vegetables that has significant anti-inflammatory effects. Its anti-inflammatory effects can be attributed in part to its ability to inhibit NF-kB binding activity, suppress the release of key interleukins and tumor necrosis factor, increase mRNA and Nrf2, and inhibit toll-like receptor 4.
In addition to its anti-inflammatory effects, research demonstrates that kaempferol also has antibacterial, antifungal, antiprotozoal, and anticarcinogenic effects. Preliminary research also shows that kaempferol can help regulate intestinal health and is a potential neuroprotective agent.
Several studies analyzing the health effects of kaempferol have been published within the last year.
New Research
A 2024 systemic review of in vitro studies found that kaempferol exerts its anticarcinogenic effects by controlling tumor cell cycle progression, proliferation, apoptosis, migration, and invasion while also inhibiting angiogenesis.
In addition, an animal study from December 2024 demonstrated that kaempferol suppressed allergic symptoms of food allergies. In that study, the researchers found that kaempferol promoted regulatory T-cell development to control the immune response.
A double-blind, placebo-controlled, randomized, crossover study from last year found that 10 milligrams (mg) of kaempferol take daily for two weeks helped improve sleep quality and overall quality of life compared to placebo.
A study from last year using bioinformatics technology concluded that kaempferol could be an effective anti-immunotherapy strategy for patients with rheumatoid arthritis (RA) because it binds to CASP1 and affects RA pyroptosis.
A review from last year also concluded that kaempferol has the potential to prevent and treat age-related diseases because of its neuroprotective and anticancer effects. The researchers explain that kaempferol addresses the hallmarks of age-related diseases because it counteracts reactive oxygen species and combats oxidative stress and inflammation.
Availability
The list of conditions that may benefit from kaempferol is long and diverse because of its potent anti-inflammatory and immunomodulatory effects. In addition to being available as a dietary supplement, foods that are high in kaempferol include beans, black tea, broccoli, carrots, cauliflower, green chili, pumpkin, and strawberries. Spices that contain kaempferol include dill, fennel, capsaicin, and oregano.
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