In humans, the gastrointestinal tract represents a large microbial ecosystem, housing several trillion microbial cells. The human gut microbiome and its role in both health and disease has been researched extensively.
Healthy adult gut microbiota are dominated by Bacteroidetes and Firmicutes but also include smaller proportions of Actinobacteria, Proteobacteria, and Verrucomicrobia .In a healthy state, the gut microbiota have myriad positive functions, including energy recovery from metabolism of nondigestible components of foods, protection of host from pathogenic invasion, and modulation of the immune system. Gut microbiota dysbiosis — imbalances in the composition and function of these intestinal microbes — is associated with diseases ranging from localized gastroenterologic disorders to neurologic, respiratory, metabolic, hepatic, and cardiovascular illnesses.
Effort is currently concentrated on exploring potential causality and related microbiota-mediated disease mechanisms, and the potential of using probiotics, prebiotics and the combination of the two (synbiotics) with the hope of restoring gut dysbiosis and slowing the progression of the disease states. This webinar provides a holistic approach to gut dysbiosis using an example of obesity as a gut related dysbiosis.