The emerging role of epigenetics in gene regulation is causing a paradigm shift in healthcare and nutrition. The Lunasin peptide with its novel epigenetic mechanism of action provides an effective and nutritional alternative against non-communicative, degenerative chronic diseases. Lunasin’s ability to turn on and off genes makes it a viable and potentially groundbreaking treatment option for chronic diseases, such as cancer and heart disease. But how and why does this peptide work and how can it be used in combination with diet and nutrition for optimal results? This report will outline the effects of Lunasin on the body, providing an overview of epigenetics and outlining the effects Lunasin has on the human body at the cellular and molecular level.