oxidative stressLaboratory Markers for Assessing Disease Risk

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Presented by: Walter Crinnion, ND
Recorded: February 2015

Oxidative damage to cells and tissues is the main mechanism behind most common disease states and all of the signs and symptoms of aging. Many things in our environment and lifestyle promote oxidative stress, including all of the common chemical and heavy metal toxicants. Severe oxidative damage is typically caused by either hydroxyl or peroxide radicals. Decades of research has provided us with documentation of the accuracy of two different markers for ongoing oxidative stress: F2 isoprostane and 8-hydroxy-deoxyquanosine (8OFdG). 8OFdG is present in the urine of all persons and is reflective of both the amount of hydroxyl radical damage to the DNA, and the ability of the DNA to repair this damage. 8OFdG levels are excellent predictors of the development and exacerbations of all of the common chronic diseases including heart disease and cancer. 8OFdG levels are also indicative of toxicant burden, and clearly reflect whether or not the person is in oxidative stress. Use of this simple urine test can allow holistic practitioners to monitor the progression of health and disease for their patients, without having to wait on symptomatic changes to know whether their therapies are working or not. It can also indicate whether a change in their diet and lifestyle has made a significant impact on their overall health.