White Papers & ReportsGoldenseal, also known as berberine, is a member of the buttercup or Ranunculaceae family. It is a low growing perennial plant with red fruit. Its root has a bright, deep yellow appearance. Goldenseal is native to and grows in the midwestern and eastern parts of the USA in woodlands, including the Ohio River Valley, West Virginia, the mountains of North and South Carolina, Kentucky, Tennessee, and north to New England and Upstate New York and parts of Quebec, Canada.