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Integrative Practitioner is the leading online resource for integrative healthcare practitioners and professionals, providing its users with access to the most up-to-date information in integrative health news, events, and resources. We aim to support the wide spectrum of integrative healthcare practitioners with educational and informative content that is relevant to their patients and beneficial to their practice.
Learn about the contrast between the blockbuster model of product development versus the long-tail model. While the blockbuster model is currently appearing in popular art in the form of music and books, the focus of this lecture will be on pharmaceuticals and crops where the result is an increasingly small number of very expensive drugs along with the loss of cheap generics, and the increasing use of genetically modified crops that are designed to be used in combination with pesticides.Read More >>
Free On Demand Webinar Presented by: Ankur R. Parikh, DO; Marie Winters, ND; and JoAnna Zammiello, RD Recorded: September 16, 2014 A clinical team from Cancer Treatment Centers of America® (CTCA) will review three case studies showcasing a patient’s navigation through the Patient Empowered Care® (PEC) model at CTCA. The PEC team will give concrete examples of how to engage in a holistic approach to quality of life for patients going through cancer care. Ankur R. Parikh, DO; Marie Winters, ND; and JoAnna Zammiello, RD from Cancer Treatment Centers of America® in Philadelphia will present a series of case studies to provide practitioners a better understanding of: • Common oncology case scenarios • The epidemiology of common cancers • General treatment protocols and potential complications • The roles of naturopathic medicine and nutrition in oncology
Gain the Whole Perspective
Make plans to attend the upcoming Integrative Healthcare Symposium focus on: the microbiome taking place October 9-10 in Hollywood, Florida. Learn from leading speakers and take a deeper look into the topic of microbiome and how it impacts you and your patients. Visit the EVENT SITE today to learn more.
With an aging population, fronted by the “baby boomers,” we are likely to see an even greater demand for anti-inflammatory and painkilling interventions in the near future.
The problem is that most over-the-counter (OTC) and prescription drugs are highly dangerous when used long term, which is the very nature of the conditions many people face. Whether they are dealing with rheumatoid arthritis (RA), osteoarthritis (OA), past injuries, or work-related wear and tear, reducing pain and protecting the joints are an ongoing issue.
And this is urgent business. Deaths from painkillers have tripled in the past decade.1 The reliance on synthetic COX-2 inhibitors has led to a dangerous cycle of dependence on medicines that only offer temporary relief at a high price to health. That is why it is critical for practitioners and all of those involved in the natural health field to promote a viable, effective, and safe alternative.
MORE WHITE PAPERS & REPORTS
Researchers Discover New Biomarker for Predicting Liver Cancer Spread and Survival
- Written by Lindsay Aouled Ezzine
New research has shown that a unique pattern of microRNAs, small RNA molecules that regulate gene activity, can accurately predict whether liver cancer will spread and whether liver cancer patients will have shorter or longer survival, even patients with early stage disease. The study, which appeared online January 7, 2008 in Hepatology, was conducted by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and colleagues at Ohio State University, Columbus, and the Liver Cancer Institute in Shanghai, China.
"The aggressive nature of hepatocellular carcinoma, a prevalent type of liver cancer, is largely due to its tendency to spread or recur after surgery," said the study's lead author, Anuradha Budhu, Ph.D., a staff scientist in the laboratory of Xin Wei Wang, Ph.D., head of the Liver Carcinogenesis Section of NCI's Center for Cancer Research (CCR). "Identifying new diagnostic and prognostic biomarkers for liver cancer is a first step in alleviating the dismal outcome of this disease."
MicroRNAs, or miRNAs, have been implicated in various aspects of human disease, including cancer. Their abundance in different tissues and cancer types indicate that miRNAs are functionally significant and have the potential to be used as cancer biomarkers. Since miRNAs can effectively regulate the activity of multiple cancer-related genes and pathways, they are prime candidates for coordinating the intricate events that lead to the spread of cancer, which is known as metastasis.
In this study, Budhu and her colleagues used miRNA microarray techniques, which allows researchers to examine the expression of thousands of genes simultaneously. They analyzed the miRNA expression profiles (shows the extent to which individual miRNAs are turned on or off) in cancerous and noncancerous liver samples from 131 patients with or without metastasis who underwent surgery at the Liver Cancer Institute and Zhongshan Hospital in Shanghai. The analysis revealed a set of 20 miRNAs with different patterns of expression in tumors with metastasis compared to tumors without metastasis. MiRNAs are capable of regulating the expression of one or more genes, including cancer-related genes, potentially affecting multiple cell functions that could lead to malignancy.
"This is an important and unique finding because it is the first study to show that miRNAs play a significant role in liver metastasis," explained Budhu. "In fact, miRNAs have not previously been related to cancer spread in any other organ."
Using the new gene expression profile, the researchers found that patients with the metastasis-miRNA profile had a two-fold higher risk of shorter survival compared to those without the profile. This latest finding in hepatocellular carcinoma, or HCC, in combination with earlier research by this team on early stage HCC and the tumor microenvironment, suggests a real potential for increasing the accuracy of liver cancer diagnosis and prognosis, as well as in monitoring recurrence.
"MiRNAs are also very stable molecules, which is an ideal property that could allow for more dependable measurements in clinical diagnostic or prognostic methods. Since miRNAs can affect multiple genes, including those related to cancer, they are also promising new targets for therapeutic approaches to liver cancer treatment," said Budhu.
HCC is the most common liver cancer diagnosed in adults and has a high prevalence in Asian and African populations. The rate of new HCC cases has been rising over the past 10 years in the United States and occurs twice as often in men as in women. HCC is a very aggressive disease; patients usually survive less than one year after diagnosis. In 2007, an estimated 19,160 Americans were newly diagnosed with liver cancer and an estimated 16,780 people died of the disease.
For more information about cancer, please visit the NCI website at http://www.cancer.gov, or call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237).
For more information on Dr. Wang's research, go to http://ccr.cancer.gov/staff/staff.asp?profileid=5764.
For more information on Dr. Budhu's research, go to http://ccr.cancer.gov/staff/staff.asp?profileid=6709.
The National Institutes of Health (NIH) — The Nation's Medical Research Agency — includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
Budhu A, Jia H, Forgues M, Liu C, Goldstein D, Lam A, Zanetti KA, Ye Q, Qin L, Croce CM, Tang ZY, Wang, XW. Identification of Metastasis-related MicroRNAs in Hepatocellular Carcinoma HEP-07-1296. Hepatology. Online January 7, 2008. Vol. 47 No. 1.
Budhu A, Forgues M, Ye Q, Jia H, He P, Zanetti KA, Kammula US, Chen Y, Qin L, Tang Z, and Wang XW. Prediction of venous metastases, recurrence and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell. August 2006, Vol. 10, Issue 2.