Family-based study that examines the relationship of pesticides and correlated lifestyle factors to Parkinson’s disease (PD) risk.
Dana B Hancock, Eden R Martin, Gregory M Mayhew, Jeffrey M Stajich, Rita Jewett, Mark A Stacy, Burton L Scott, Jeffery M Vance and William K Scott
Pesticides and correlated lifestyle factors (e.g., exposure to well-water and farming) are repeatedly reported risk factors for Parkinson’s disease (PD), but few family-based studies have examined these relationships.
Using 319 cases and 296 relative and other controls, associations of direct pesticide application, well-water consumption, and farming residences/occupations with PD were examined using generalized estimating equations while controlling for age-at-examination, sex, cigarette smoking, and caffeine consumption.
Overall, individuals with PD were significantly more likely to report direct pesticide application than their unaffected relatives (odds ratio=1.61; 95% confidence interval, 1.13-2.29). Frequency, duration, and cumulative exposure were also significantly associated with PD in a dose-response pattern (p<0.013). Associations of direct pesticide application did not vary by sex but were modified by family history of PD, as significant associations were restricted to individuals with no family history. When classifying pesticides by functional type, both insecticides and herbicides were found to significantly increase risk of PD. Two specific insecticide classes, organochlorines and organophosphorus compounds, were significantly associated with PD. Consuming well-water and living/working on a farm were not associated with PD.
These data corroborate positive associations of broadly defined pesticide exposure with PD in families, particularly for sporadic PD. These data also implicate a few specific classes of pesticides in PD and thus emphasize the need to consider a more narrow definition of pesticides in future studies.
The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production
BMC Neurology 2008, 8:6doi:10.1186/1471-2377-8-6
Published: 28 March 2008
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Additional articles on this topic: